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There were differences in the amount of body fat and weight reduction body revolution that might be explained by variability in genes involved in estrogen and androgen production. Advance: To test this new hypothesis, researchers enrolled 50-75 year-old postmenopausal women in a 225 minutes/week moderate exercise program for one year. Genetic polymorphisms for two genes, CYP19 and COMT, involved in the conversion of estradiol into testosterone or less active body revolution metabolites were examined. Exercisers with the CYP19 polymorphism had a larger decrease in total fat (7 pounds lost vs. 1 pound) and percentage body fat (2.4% for 0.6%). Those women with the COMT polymorphism had a smaller decrease in percentage body fat (0.7% vs. 1.9%). Implication: These results suggest that genetic polymorphisms in at least two genes, CYP19 and COMT, may be important for body fat regulation.

or e-mail power lifting me power lifting Environmental Health News Highlights in Environmental Health Sciences Research Genetic Differences and Effects on Exercise-Induced Fat Loss in Post-Menopausal Women Genetic Differences and Effects on Exercise-Induced Fat Loss in Post-Menopausal Women Shelley S. Tworoger, Ph.D. Harvard Medical School and Brigham and Women's Hospital 32ES07262 and P30ES07033 Background: Many research studies have shown that postmenopausal women with high body fat content power lifting and high body mass index (BMI) are at increased risk of developing chronic diseases such as coronary heart disease, stroke, type 2 diabetes, colo-rectal cancer, and breast cancer. Strategies to reduce body fat content and obstacles to weight reduction are important factors to identify to aid in preventing these serious illnesses. These authors have previously shown that women who participated in a year-long moderate-intensity exercise intervention reduced their BMIs and lost body fat compared to women who maintained a sedentary lifestyle.

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