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Hypothesis 2: Exercise intensity fatfree or lowfat will in a dose-dependent fashion increase basal increase insulin resistance Recently we observed that increased exercise intensity during 15 to 30 weeks of training interferes with increases in insulin sensitivity in postmenopausal women that is contrary to the usual reports of increased muscle sensitivity to insulin following exercise training. In our pilot study, training of 15 to 30 weeks’ duration increased insulin sensitivity (assessed by the indirect measure of postprandial insulin response (PPAUC) fatfree or lowfat to a standardized evening meal) at slowest walking speeds and caused insulin resistance at fastest walking speeds (Figure 9). No change fatfree or lowfat or increases in PPAUC are indicative of no increases in insulin sensitivity or increases in insulin resistance at high walking speeds. In the present study, insulin sensitivity (SI) mesured with the frequently-sampled intravenous glucose tolerance test (FSIVGTT), was inversely related to training intensity in women who did not lose more than 3% of the body fat during training (Figure 10).
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