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Strategies to reduce body fat content and obstacles to weight reduction are important factors to identify to aid in preventing these serious illnesses. These authors have previously shown health/fitness that women who participated in health/fitness a year-long moderate-intensity exercise intervention reduced their BMIs and lost body fat compared to women who maintained a sedentary lifestyle. There were differences in the amount health/fitness of body fat and weight reduction that might be explained by variability in genes involved in estrogen and androgen production. Advance: To test this new hypothesis, researchers enrolled 50-75 year-old postmenopausal women in a 225 minutes/week moderate exercise program for one year. Genetic polymorphisms for two genes, CYP19 and COMT, involved in the conversion of estradiol into testosterone or less active metabolites were examined. Exercisers with the CYP19 polymorphism had a larger decrease in total fat (7 pounds lost vs.
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