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| weight loss drug, russian, transformation, stone, coaches, fat information, davidknowles, cardiotraining, ageing, accu measure, cathy friedrich, woman's fitness, weight loss nutrition program, | This confirms observations of others that leptin is positively high altitude training related to body fat at all fatness levels. It also suggests that a steep decline in plasma leptin concentration is triggered by exercise training at the point in time when body fat high altitude training losses approach 5%. Training intensity effects on circadian pattern of leptin high altitude training concentration. When plasma leptin concentrations are plotted on an hourly basis in fast walking and slow walking women, no effect of training is seen before women start training (Figure 4) and after 15 weeks of training (not shown). Figure 3: The relationship between Figure 4: Circadian pattern of nocturnal plasma leptin and body fat at three plasma leptin concentration before the experimental time points start of training After 30 weeks of training, however, exercise-trained group displays significantly lower plasma leptin concentrations along with attenuation of nocturnal leptin peak (Figure 5). |
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| This research is a collaboration with Dr. Josephine Kasa-Vubu and is also transformation supported by a Clinical Research Partnership transformation (UM Medical School). Training intensity had no effect on plasma leptin concentration (which was proportional to body fat level) until 30 weeks of training at which point there was a significant negative correlation between plasma leptin concentration and training intensity (R=-0.715, f=7.332, P=0.03, Figure 2). Relationship between body fat level and plasma leptin. Since fast walkers lost increasing amounts of body fat transformation to a 5% loss attained after 30 weeks of walking, it was of interest to see whether the relationship of plasma leptin to training intensity could be a consequence of training-induced fat loss. When plasma leptin is examined as a function of body fat level at three time points in the study, there is a positive linear relationship between the two variables before the beginning of training and after 15 and 30 weeks of training (Fig 3). |
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